Interaction of Telomere Length and Inflammatory Biomarkers Following Zirconia Implant Placement: A Case Series
Zirconia implants have gained popularity for their aesthetic appeal and biocompatibility, making them a preferred choice for anterior teeth replacement. This study explores the interaction between telomere length and inflammatory biomarkers in seven cases of zirconia implant placement to gain insights into postoperative cellular aging, inflammatory responses, and long-term outcomes. Zirconia implants offer advantages over titanium implants, as they do not corrode or release metal ions, leading to potential inflammation and implant failure. Monitoring immune and inflammatory biomarkers is essential to assess inflammation initiation, severity, and progression. C-reactive protein (CRP) and pro-inflammatory cytokines, like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), play crucial roles in host immune responses, while anti-inflammatory cytokines, including interleukin-10 (IL-10), regulate and dampen immune responses. Achieving a delicate balance between pro- and anti-inflammatory cytokines is vital for maintaining a healthy immune response and preventing chronic inflammatory conditions. Telomeres, protective structures present at chromosome ends, influence cellular aging and mitochondrial function. Shorter telomeres are associated with impaired mitochondrial function, increased oxidative stress, and cellular senescence, while longer telomeres are linked to reduced inflammation and improved immune function. Understanding these mechanisms is essential for addressing age-related conditions and promoting overall well-being. In this case series, we investigated the interaction between telomere length and inflammatory biomarkers in patients who received zirconia dental implants. The study aims to improve our understanding of postoperative cellular aging, inflammatory responses, and the biocompatibility of zirconia implants, potentially leading to improved treatment protocols and patient outcomes. This innovative assessment of telomere length and inflammatory biomarkers in the context of zirconia implants provides novel insights into the field of dental implantology. By exploring the effects of zirconia implants on cellular health and inflammation, this study contributes to advancements in implant technology and patient care.
Panoramic radiographs were obtained (a) before surgery, (b) immediately after surgery, and (c) after prosthetic rehabilitation. Clinical oral photographs were taken (d) before surgery, (e) immediately after surgery, and (f) after prosthetic rehabilitation. Photographs of the upper and lower arches were taken using intraoral mirrors and therefore appear inverted.
Clinical aspects of the oral mucosa, occlusal bite, and smile after occlusal rehabilitation.
Pre- and postoperative blood inflammatory cytokine levels and CRP/IL1-β values in relation to study inclusion criteria. The graph displays the mean values of the measurements, with error bars representing the standard deviation. CRP, C-reactive protein; IFN, interferon; IL, interleukin; TNF, tumor necrosis factor.
Pre- and postoperative telomere length (Telo) and bioenergetic health index (BHI). The graph displays the mean values of the measurements, with error bars representing the SD. SDS, Swiss Dental Solutions.
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