Editorial Type:
Article Category: Research Article
 | 
Online Publication Date: 01 Jun 2017

Comparison of Bovine Bone-Autogenic Bone Mixture Versus Platelet-Rich Fibrin for Maxillary Sinus Grafting: Histologic and Histomorphologic Study

DDS,
DDS,
DDS,
PhD,
MD, and
DDS
Page Range: 194 – 201
DOI: 10.1563/aaid-joi-D-16-00104
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Numerous grafting materials have been used to augment the maxillary sinus floor for long-term stability and success for implant-supported prosthesis. To enhance bone formation, adjunctive blood-born growth factor sources have gained popularity during the recent years. The present study compared the use of platelet-rich fibrin (PRF) and bovine-autogenous bone mixture for maxillary sinus floor elevation. A split-face model was used to apply 2 different filling materials for maxillary sinus floor elevation in 22 healthy adult sheep. In group 1, bovine and autogenous bone mixture; and in group 2, PRF was used. The animals were killed at 3, 6, and 9 months. Histologic and histomorphologic examinations revealed new bone formation in group 1 at the third and sixth months. In group 2, new bone formation was observed only at the sixth month, and residual PRF remnants were identified. At the ninth month, host bone and new bone could not be distinguished from each other in group 1, and bone formation was found to be proceeding in group 2. PRF remnants still existed at the ninth month. In conclusion, bovine bone and autogenous bone mixture is superior to PRF as a grafting material in sinus-lifting procedures.

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  <sc>Figure 1</sc>
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Figure 1

Extraoral approach to the maxillary sinus.


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  <sc>Figure 2</sc>
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Figure 2

(a) Preparation of bone mixture. (b) Placement of bone mixture. and (c) Placement of PRF into the subsinus cavity. (d) Closure of the window with collagen membrane.


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  <sc>Figure 3</sc>
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Figure 3

Volume calculations of bone formation. (a) Magnification, ×4. (b) Magnification, ×20.


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  <sc>Figure 4</sc>
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Figure 4

Histologic view of the sinus membrane and host bone in controls (hematoxylin and eosin, magnification ×4). S indicates sinus cavity; SE, sinus epithelium; LP, lamina propria; P, periosteum; MG, mucous glands; B, bone.


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  <sc>Figure 5</sc>
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Figure 5

(a) Histologic view of newly formed bone at the third month. (b) Cartilage tissue gradually replaced with new bone trabecules in connective tissue at the sixth month. (c) New bone could not be distinguished from the host bone at the ninth month in graft groups. (d) Platelet rich fibrin (PRF) particles surrounded by compact fibrous capsules at the third month. (e) Newly formed bone was seen between the connective tissue and the host bone at the sixth month. (f) New bone formation is still continuing at the ninth month in PRF groups. S indicates sinus cavity; SE, sinus epithelium; LP, lamina propria; P, periosteum; PR, PRFremnants; HB, host bone; NB, new bone; MG, mucous glands; ED, edema.


Contributor Notes

Corresponding author, e-mail: hakanocak82@hotmail.com
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