Saliva Versus Peri-implant Inflammation: Quantification of IL-1β in Partially and Totally Edentulous Patients
The aim of this study was to investigate the potential use of salivary IL1β in early-stage diagnostics of peri-implant inflammation in partially and totally edentulous patients rehabilitated with dental implants. Patients were classified according to peri-implant probing depth and bleeding upon probing in groups of healthy individuals or in groups of individuals with peri-implant inflammation. Data on plaque index, clinical attachment loss, suppuration, and mobility were also assessed. Saliva was collected without stimulation, and the levels of IL-1β were determined by ELISA. Healthy groups demonstrated significantly lower levels of IL-1β compared with the inflammation groups. No difference in IL-1β levels was observed between partially edentulous or totally edentulous patients. Salivary IL-1β may be useful for the diagnosis and monitoring of early peri-implant inflammation, particularly in edentulous patients.
Figure 1. Clinical peri-implant pocket depth (IPPD) in the evaluated groups (**P < .01). Figure 2. Frequency distribution of Modified plaque index score (mPI) in the evaluated groups (**P < .01). Figure 3. IL1β levels in Group I - Control, Group II – Healthy, and Group II – Inflammation (*P < .05). Figure 4. IL1β levels in Group I - Control, Group III – Healthy, and Group III – Inflammation (**P < .01). Figure 5. IL1β levels in Healthy (a) and Inflammation (b) condition.
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