Editorial Type:
Article Category: Other
 | 
Online Publication Date: 01 Dec 2012

Bone Morphogenic Protein: An Elixir for Bone Grafting—A Review

MD,
MD, and
DMD, PhD
Page Range: 767 – 778
DOI: 10.1563/AAID-JOI-D-10-00196
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Bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the transforming growth factor beta superfamily. This literature review focuses on the molecular biology of BMPs, their mechanism of action, and subsequent applications. It also discusses uses of BMPs in the fields of dentistry and orthopedics, research on methods of delivering BMPs, and their role in tissue regeneration. BMP has positive effects on bone grafts, and their calculated and timely use with other growth factors can provide extraordinary results in fractured or nonhealing bones. Use of BMP introduces new applications in the field of implantology and bone grafting. This review touches on a few unknown facts about BMP and this ever-changing field of research to improve human life.

Keywords: BMP ; bone morphogenic proteins ; bone grafts ; transforming growth factor beta ; BMP-2 ; BMP-4 ; SMADS
Copyright: 2012
<bold> <sc>Figure 1</sc> </bold> .
Figure 1 .

Structure of bone morphogenic proteins showing cysteine knot.

<bold> <sc>Figure 2</sc> </bold> .
Figure 2 .

BMP receptor binding and signal transduction.

<bold> <sc>Figure 3</sc> </bold> .
Figure 3 .

Other pathways of BMP signaling.

<bold> <sc>Figure 4</sc> </bold> .
Figure 4 .

Intranuclear events and Wnt-catenin pathway.

<bold> <sc>Figure 5</sc> </bold> .
Figure 5 .

Role of BMPs in different stages of osteocyte development.

Contributor Notes

*  Corresponding author, e-mail: shahprasun@hotmail.com
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