Editorial Type:
Article Category: Research Article
 | 
Online Publication Date: 01 Dec 2008

Effect of Systemic Intermittent Administration of Human Parathyroid Hormone (RHPTH[1–34]) on the Resistance to Reverse Torque in Rabbit Tibiae

DDS, MS,
DDS, MS, PhD,
DDS, MS,
DDS,
DDS, MS, PhD, and
MS, PhD
Page Range: 298 – 302
DOI: 10.1563/1548-1336-34.6.298
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Abstract

The aim of this study was to evaluate the effect of intermittent administration of human parathyroid hormone [rhPTH (1–34)] on the removal torque of implants placed in rabbit tibiae. Twenty male New Zealand rabbits were submitted to implant surgery. Each animal received one machined screw-type implant (3.75 mm diameter × 8 mm length) in the proximal metaphysis of the right tibia. The rabbits were then divided into 2 groups: the test group (n = 10) received 6 μg/kg of rhPTH (1–34) subcutaneously in the dorsal region 3 days a week, and the control group (n = 10) received placebo. Removal torque was performed at 28 and 56 days after implant placement for both groups. The mean removal torque values at 28 days were 37.0 ± 4.36 Ncm and 47.4 ± 6.77 Ncm for control and test groups respectively (P < .05). At 56 days the reverse torque was 45.8 ± 3.96 Ncm for the control group and 55.8 ± 2.86 Ncm for the test group, indicating that the removal torque was significantly higher in the test groups (P < .05). These results demonstrated that intermittent treatment with rhPTH (1–34) enhanced the removal torque of implants in rabbit tibiae.

Copyright: American Academy of Implant Dentistry
Figure 1.
Figure 1.

Mean + standard deviation of the removal torque values in each group for 28 and 56 days. Mann-Whitney test (difference between groups) P < .05; Wilcoxon test (intragroup differences) P > .05; ns = nonsignificant


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