Histologic Analysis of Human Peri-Implant Bone in Type 1 Osteoporosis
Osteoporosis is a disease that influences the quality of bone tissue. At present, osteoporosis represents a contraindication or a risk factor for osseointegration. The aim of this report was to evaluate the bone-to-implant contact of 2 loaded implants retrieved after prosthetic failure in a woman with type 1 osteoporosis. Histologically, only one implant was osseointegrated, and it appeared surrounded by healthy bone tissue. The bone-to-implant contact presented a mean of 51.25%. No foreign body reaction was found at the bone-to-implant contact, although epithelial downgrowth was observed at the interface. Data from this case report demonstrate that the peri-implant bone histology of the dental implant retrieved from an osteoporotic patient presented no alteration. However, the role of osteoporosis in the long-term success of dental implants needs further investigation.Abstract
and 2. Figure 1. Primary osteoporosis (type 1, postmenopausal osteoporosis) determined by DPX-IQ AP in the lumbar spine based on the World Health Organization T-scores: T-score <2.5 standard deviation. Figure 2. Radiographic view of the retrieved implants (labeled with red circle).
and 4. Figure 3. Ground section of retrieved dental implant depicting lack of osseointegration and soft tissue (*) (basic fuchsin and toluidine blue staining, original magnification ×16). Figure 4. Histologic ground section of the implant retrieved from the maxilla (basic fuchsin and toluidine blue staining). (a) Broken implant showing pristine bone mostly lamellar and compact (original magnification ×16); (b) detail of the red frame shown in Figure 4a. There is an apposition of bone in close contact with the implant surface (original magnification ×40); (c) detail of the frame shown in Figure 4b. The bone tissue was mostly compact, and some osteocytes were presented in their lacunae (original magnification ×100).
Contributor Notes
Jamil Awad Shibli, DDS, MS, PhD, is an assistant professor in the Department of Periodontology, Dental Research Division, and head of the Oral Implantology Clinic, Guarulhos University, Guarulhos, São Paulo, Brazil. Address correspondence to Dr Shibli at Centro de Pós-graduação, Pesquisa e Extensão – CEPPE. Universidade Guarulhos-UnG. R. Dr Nilo Peçanha, 81 – Prédio U – 6° Andar. 07011–040, Brazil. (jshibli@ung.br)
Kelly Christine Dias de Souza Aguiar, DDS, MS, Leandro Melo, DDS, MS, and Daniel Sanchez Ferrari, DDS, are graduate students and Susana d'Avila, DDS, MS, PhD, is a researcher in the Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.
Giovanna Iezzi, DDS, PhD, is a researcher, Dental School, University of Chieti, Chieti, Italy.
Adriano Piattelli, MD, DDS, is a professor of Oral Medicine and Pathology, and the dean and director of Studies and Research, Dental School, University of Chieti, Chieti, Italy.