Use of Platelet-Rich Plasma in the Management of Oral Biphosphonate-Associated Osteonecrosis of the Jaw: A Report of 2 Cases
Bisphosphonates (BP) are nonhormonal medications used in the treatment of various bone malignancies and metabolic conditions. Since 2003, there have appeared a significant and growing number of articles in the worldwide medical and dental literature describing the complication of an osteonecrosis of the jaws associated with the intravenous and, most recently, the oral form of BP medication that has been refractory to any definitive form of treatment. The authors have successfully managed 2 patients taking the oral form of BP with adjunctive treatment using platelet-rich plasma (PRP), and in one case with hyperbaric oxygen (HBO). We were able to obtain complete remission in each case, which is defined as resolution of pain and complete closure of exposed bone in the jaws. The purpose of this report is to describe a treatment protocol and the rationale for using PRP and HBO to obtain complete remission of this new pathologic condition.Abstract


Contributor Notes
Cameron Y. S. Lee, DMD, MD, is in private practice in oral and maxillofacial surgery, Aiea, Hawaii. Address correspondence to Dr Lee at 98–1247 Kaahumanu Street, Suite 314, Aiea, Hawaii 96701 (CLee555294@aol.com).
Teresa David, DO, is a medical officer with the Hyperbaric Treatment Center, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii.
Michael Nishime, DDS, is in private practice in cosmetic and implant dentistry, Honolulu, Hawaii.