The Effect of a Biphasic Ceramic on Calvarial Bone Regeneration in Rats
Bioactive ceramics (calcium phosphate ceramics, hydroxyapatite ceramics) are now extensively used in oral surgery. The purpose of this study was to assess the effect of a new biphasic ceramic (Ceraform) on the osteogenesis in a rat calvarial defect model. Fifteen Wistar rats were used in this study. Two symmetrical 3-mm wide defects were created in the skull of each rat. The left defect was left empty as a control and the right defect was filled with the ceramic. The rats were sacrificed at day 30, and the calvarial specimens were processed for qualitative and quantitative histological examinations. The material exhibited no adverse effects, but no bone healing was noted either. No statistical difference regarding bone regeneration was observed between the 2 defects (P > .05). This study showed that Ceraform did not elicit any inflammatory reaction; however, it had no effect on bone regeneration, and this material seems suitable only as a space-maintaining material.Abstract
Contributor Notes
Hakan Develioğlu, DDS, PhD, is with the Department of Periodontology, Emel Koptagel, ProfDr, is with the Department of Histology-Embryology, and Rüştü Gedik, DDS, PhD, is with the Department of Oral Diagnosis-Radiology, Faculty of Dentistry, Cumhuriyet University, Sivas, Turkey. Address correspondence to Dr Hakan Develioğlu, Cumhuriyet Üniversitesi Dişhekimliği Fakültesi, Periodontoloji Anabilim Dalı-Kampüs, 58140 Sivas, Turkey (hdevelioglu@mynet.com.tr).
Laurent Dupoirieux, MD, DMD, PhD, is with the Institute of Surgical Research, Montpellier, France.