Editorial Type:
Article Category: Research Article
 | 
Online Publication Date: 01 Jul 1999

Effect of Freeze-dried Bone and a Dextran Agglutinant on the Healing of Defects in the Rat Mandible

DDS, MS, DSc,
DDS, MS, DDSc,
DDS, and
DDS, PhD
Page Range: 203 – 206
DOI: 10.1563/1548-1336(1999)025<0203:EOFDBA>2.3.CO;2
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Abstract

The effects of inorganic, freeze-dried bone, alone or mixed with a dextran agglutinant, on the repair of experimentally created critical-size bone defects were evaluated in the rat mandible. Histological data demonstrated a progressive resorption of the freeze-dried bone particles, without osseous proliferation into the defect, and a posterior foreign-body reaction. These results indicate that the freeze-dried bone did not induce bony healing in the critical-size defect and that the addition of dextran agglutinant did not change the tissue response. Dextran may have other applications as a biocompatible, resorbable agglutinant.

Copyright: American Academy of Implant Dentistry
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